Classification ntawm hirsutism

Hirsutism yog hais txog kev loj hlob ntawm cov plaub hau ntev, nrog rau cov plaub hau ntau dhau ntawm qhov loj xws li daim di ncauj, lub puab tsaig, pob ntseg, lub puab tsaig, lub plab mog, nraub qaum, hauv siab thiab cov ceg tawv. Qhov tshwm sim yog 5% mus rau 10% hauv cov poj niam uas muaj hnub nyoog me nyuam. Tus kab mob tuaj yeem yog thawj qhov tshwm sim ntawm androgen ntau dhau.

1.2.1 Physiological hirsutism

Physiological hirsutism, tseem hu ua idiopathic hirsutism, muaj qhov pom tseeb ntawm tsev neeg nyiam. Cov neeg mob no yuav tsis cuam tshuam los ntawm cov yam ntxwv xws li endocrine thiab qog, thiab tus nqi ntawm androgens hauv lawv cov ntshav yog qhov qub. Txawm li cas los xij, vim hais tias cov hauv paus plaub hau yog rhiab rau cov qib androgens tsawg, hirsutism tseem tuaj yeem tshwm sim.

1.2.2 Pathological hirsutism tshwm sim los ntawm cov kab mob metabolic thiab endocrine

Cov kab mob endocrine feem ntau yog polycystic zes qe menyuam syndrome (PCOS), suav txog 72% mus rau 82% ntawm cov neeg mob hirsutism. Cov yam ntxwv tseem ceeb ntawm congenital adrenal hyperplasia (CAH) yog ntau dhau ntawm androgen ntau lawm.<5% of patients with hirsutism have adrenal cortical hyperplasia. Affected women show hirsutism from peri-puberty onwards, often accompanied by irregular menstruation. Symptoms such as regular or primary amenorrhea. Severe insulin resistance syndrome can stimulate the adrenal glands and ovaries to produce more androgens, while hyperinsulinemia inhibits the liver's synthesis of sex hormone-binding globulin, thereby increasing the concentration of total serum testosterone and causing hirsutism in patients. Hyperprolactinemia, acromegaly, and hypothyroidism are also less common causes of hirsutism.

Androgen-secreting qog, zes qe menyuam theca cell hyperplasia, adrenocorticotroph adenomas, thiab cov kab mob ntawm zes qe menyuam tsis zoo kuj feem ntau cuam tshuam nrog hirsutism vim muaj ntau dhau ntawm androgen secretion.

1.2.3 Cov teebmeem thib ob ntawm cov tshuaj

Kev siv cov tshuaj androgen xws li testosterone los yog dehydroepiandrosterone, xws li danazol, tej zaum yuav cuam tshuam nrog kev loj hlob ntawm hirsutism. Ib qho kev mob tshwm sim ntawm kev siv tshuaj tiv thaiv kab mob xws li cyclosporine yog hirsutism. Lwm cov tshuaj muaj xws li acetazolamide, citalopram, adrenocorticotropic hormone, corticosteroids, metoclopramide, methyldopa, minoxidil, reserpine, streptomycin, sodium valproate, thiab hnyav hlau thiab lwm yam.

1.2.4 Lwm yam kab mob uas tsis yog endocrine

Hirsutism kuj tuaj yeem tshwm sim hauv cov neeg mob uas muaj qee yam kab mob hauv lub cev, suav nrog porphyria, anorexia nervosa, kev noj zaub mov tsis zoo, cov menyuam yaus dermatomyositis, tuberculosis, hypothyroidism, thiab txawm tias paraneoplastic syndromes.